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Titration step values follow the REDEFINE Phase 3 protocol structure as reported by Novo Nordisk and the NEJM publications

[5] 6-Phosphogluconate + NADP + Ribulose 5-phosphate + NADPH + CO 2 Catalytic mechanism of 6-phosphogluconate dehydrogenase The catalytic mechanism of 6-phosphogluconate dehydrogenase closely resembles that of isocitrate dehydrogenase (EC 1.1.1.41), a key enzyme of the citric acid cycle

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