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GLP-1 Receptor Distribution: **Brain: Hypothalamus, brainstem (appetite, satiety, nausea signaling) GI tract: Slows gastric emptying Heart: Cardioprotective signaling (modest direct effects
Pratley, Medical Director at the AdventHealth Diabetes Institute Orlando, FL and Co-Chairman of the FLOW Trial
Ozempic compared to Bydureon led to: lower blood sugars based on HbA1c compared to about 0.6% (-1.5%vs 0.9%)
Liraglutide has been reported to lower the BMI by approximately 5% (55) and semaglutide with an average of 15% compared to a placebo (56)
Insulin regulation It stimulates glucose-dependent insulin secretion, meaning insulin is released in response to blood sugar elevation not independently, which lowers the risk of hypoglycaemia in non-diabetic patients
