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EVs are exceptional drug delivery vehicles and have emerged as powerful alternatives for tailored distribution of drugs to treat neurological diseases, as they are biocompatible and stable in circulation for several days (137, 138)

Antioxidants 13(3):254 Massa CM, Liu Z, Taylor S, Pettit AP, Stakheyeva MN, Korotkova E, Popova V, Atochina-Vasserman EN, Gow AJ (2021) Biological mechanisms of s-nitrosothiol formation and degradation: how is specificity of s-nitrosylation achieved

doi:10.1111/jpi.12025

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This reinforces the value of interpreting both statistical and clinical indices when evaluating outcomes in heterogeneous populations such as individuals with T21

Kornblau SM, Qiu YH, Graber G, Chen W, Melendez J, Konopleva M, Faderl S, Andreeff M , Borthakur G, Yao H, Coombes KR