Is that true
- Erika Hello, I guess that I dont know where to start without boring you, so Ill be as brief as possible
Unlike direct GPX4 inhibition, which remains difficult to deploy in vivo owing to bioavailability and systemic toxicity concerns, targeting enzymes that sustain the reduced CoQ 10 (CoQ 10 H 2 , ubiquinol) pool may provide a more tractable and context-selective strategy to lower the ferroptotic threshold in tumors
Cell apoptosis was quantified via Annexin V-FITC/PI staining followed by flow cytometric analysis, differentiating early and late apoptotic cells
Using high-throughput screening, we subsequently identify AG1, a small molecule that increases the activity of the wild-type, the Canton mutant and several other common G6PD mutants
Each is fine on a normal day