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1999 (Pharm Res) Type Phase I PK/PD Subjects 40 healthy male volunteers Key Finding Dose-proportional pharmacokinetics

If you do experiment, introduce one product at a time

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GI side effects additive | Nausea/vomiting amplified | Minor | Titrate metformin dose slowly

To build the model, only features with less than 30% of subject data missing were used

Preclinical studies have also revealed that dual agonists of GLP-1R and glucose-dependent insulinotropic polypeptide receptor (GIPR) have synergistic anti-inflammatory and neuroprotective effects, suggesting the potential advantages of multitargeting strategies (Yuan et al., 2024)