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Dulaglutide 0.75 mg (n = 251) resulted in a mean increase in 24-h HR of 1.3 bpm, whereas a 3.5-bpm increase in HR was observed at the end of the study for the 1.5-mg dose (n = 254)

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How GLP-1 Microdosing Works Sub-therapeutic initiation dosing begins well below standard protocols, reducing early GI side-effect risk Gradual dose escalation titration is slower than standard schedules, allowing adaptation at a comfortable pace Maintained metabolic benefits even at lower doses, GLP-1 receptor activation improves appetite regulation, insulin sensitivity, and glucose metabolism Continuous personalized optimization doses are adjusted based on clinical response, weight trajectory, and patient tolerance Who Is Microdosing GLP-1 Therapy the Right Fit For in Irvine

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