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Type 2 diabetes Retatrutide has been studied in people with type 2 diabetes in a separate Phase 2 trial published in The Lancet

The plasma half-life of approximately six days supports once-weekly subcutaneous dosing in published trials

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2021 [cited 2025 October 21].Available from: Silverman DN, Plante TB, Infeld M, et al

379 The secretion of cytokines, including IFN- and TNF-, further disrupts cancer cell OXPHOS, induces mitochondrial stress, and reduces metabolic plasticity, ultimately enhancing immune-mediated cytotoxicity

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