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For a patient starting at 155/95 mmHg, that combined effect could bring readings into the 130 to 140 range, which aligns with 2017 ACC/AHA hypertension guideline targets [6]

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Zhou M, Wu X, Luo J, Yang G, Lu Y, Lin S, et al

Metformin, a drug used to treat type 2 diabetes, can also decrease absorption of B12 in the small intestine of 10 percent to 30 percent of patients