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GLP-1 At the end of 2014, liraglutide 3mg became the first GLP1R agonist approved for the treatment of obesity, which is approximately twice the highest dose used in T2D therapy

Its plotter focuses on visualization of semaglutide, tirzepatide, and retatrutide levels with particular attention to the dose increase planning feature

This review paper highlights preclinical and clinical studies indicating that GLP-1 drugs, including low dose formulations such as exenatide, may offer neuroprotective benefits by targeting hallmarks of brain aging through enhancing DNA repair, boosting antioxidant responses, reducing inflammation and improving mitochondrial function

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Similar to all medications approved for weight management, it should be prescribed along with diet, exercise and counseling when needed