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Figure 1 Despite these advances, an integrated framework explaining how capsaicin orchestrates its multitarget actions across metabolic and cardiovascular systems in CMS remains incomplete

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13 In this review, we summarise the evidence related to the effects of GLP-1 RAs on these outcomes ( Figure 1 ), which may shed light on the potential of these agents to be used in the clinical care of HF patients and investigated in large clinical trials to evaluate clinical outcomes

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GIP Activation GIP receptors play a role in metabolic efficiency and insulin response

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Signaling pathways of GLP-1R in pancreatic -cell [11] In addition to the Gs/cAMP signaling pathway, GLP-1R can also couple with other G protein subtypes, such as Gi, Gq, Go, and G11

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