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Differences among more than two groups were analyzed using one-way ANOVA or two-way ANOVA with GraphPad Prism 9.0 software (GraphPad Software, Inc

Alternative Medicine Review, 3(3), 187-198

and reduced BMI (7%), waist circumference (3%), and abdominal fat (17%) (Aziz, Hussain, Mahwi, Ahmed, Rahman 2018)

Upon activation by PAMP detection, the coral PO-like cascade employs several compounds to hydroxylate mono-phenol and diphenol substrates in melanin polymeric deposits that produce highly cytotoxic defenses and create barriers to infection (Traylor-Knowles and Connelly 2017

doi: 10.1161/01.cir.0000441139.02102.80 7

If this occurs, reducing the dose and slowly tapering up can often help