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Patients should receive comprehensive injection technique training, including proper subcutaneous administration in the abdomen, thigh, or upper arm, with site rotation to prevent lipohypertrophy
It is this rapid expansionwhich has persisted even after GLP-1s were removed from the FDA drug shortage listthat prompted the introduction of the SAFE Drugs Act and has simultaneously driven heightened FDA oversight
Rare but serious risks include allergic reactions (including anaphylaxis in very rare cases), liver stress with prolonged high-dose use, and excessive skin lightening with unregulated dosing
A large registry-based study from Denmark showing that people with IBD treated with GLP-1 RA had a lower risk of IBD-related adverse clinical events compared with those receiving other antidiabetics
Lipid Res ., 34 , 1451-1455
