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SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells

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In studies in adults with obesity or overweight with risk factors like high blood pressure or high cholesterol, the percentage of patients losing at least 10% of their body weight were 37% (taking the 7.5 mg/46 mg dose) and 48% (taking 15 mg/92 mg dose), compared to 7% of those taking a placebo

doi: 10.2337/db13-1563 53 MiyawakiKet al

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