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Birth issues: The FDA recommends GLP-1s not be taken during pregnancy and be discontinued at least two months prior to pregnancy, because animal studies demonstrate it may cause higher rates of miscarriage and birth defects
This initial phase represents the period of greatest metabolic response, when the body is adapting to the appetite-suppressing effects of the dual-receptor mechanism
Semaglutide is recommended as an option: As monotherapy when metformin is contraindicated or not tolerated, or In dual or triple therapy combinations when a GLP-1 receptor agonist is appropriate (for example, when further glucose control is needed and weight loss would be beneficial, or when other treatments are unsuitable)
The medication works by mimicking the incretin hormone GLP-1, which stimulates insulin secretion, suppresses glucagon release, and slows gastric emptying
Researchers found that exposure to the medication was similar across all groups compared with people with normal liver function
