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222 Furthermore, TLR priming induces NLRP3 ISGylation, a PTM where ISG15 ubiquitin-like modifier (ISG15) covalently binds to the target protein, stabilizing the NLRP3 protein

All analyses were carried out with the GraphPad Prism 4.0 software (GraphPad Software, San Diego, CA, USA)

10.1016/j.cmet.2019.08.021 11

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L-carnitine infusion does not alleviate lipid-induced insulin resistance and metabolic inflexibility