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TIP3P water molecules 49 were added to the simulation box (final dimensions 126 x 126 x 186 ) using the VMD Solvate plugin 1.5 (VMD Solvate plugin, Version 1.5

The mean duration of exposure to the study drug was 690 days in the lixisenatide group and 712 days in the placebo group

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Mice were studied as described in Figure 1A, and pancreatic sections were costained for insulin and glucagon

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