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SGLT2 inhibitors using inverse-probability-censoring weighted Cox proportional hazards models

Material and methods Study design and population We applied a new-user, active comparator cohort study design, comparing GLP-1 RA users with SGLT-2 inhibitor users and GLP-1 RA users with DPP-4 inhibitor users on the incidence of suicide or suicide attempts [19], utilizing information from registers on the entire Danish population [20]

GLP-1RAs have been shown to reduce the activation of nuclear factor-kappa B (NF-B), a key regulator of inflammatory responses, thereby decreasing the production of pro-inflammatory cytokines such as TNF-, IL-6, and IL-1

Fukunaga K, Shinoda Y, Tagashira H

The drugs in question are glucagon-like peptide-1 receptor agonists (GLP-1 RAs), the best known of which is semaglutide (sold commercially as Ozempic and Wegovy)

Pope and Dixon, 2023a)