The rationale for the first engineered GLP-1/GCGR co-agonist [114] originated from the observation that chronic administration of a water-soluble form of glucagon not only decreased body weight in mice with DIO, but also improved glucose tolerance with an efficacy similar to that obtained with exendin-4 [70]
If your goal is testosterone enhancement, other approaches may be more appropriate
Whether it is taken pre- or post-workout isn't considered an important factor, and taking it after exercise can also be effective for recovery and weight loss support
One B12 shot a monthdoes it cut the mustard
Who Should Be Especially Cautious
Several mid-stage trials will read out in 2025 to provide important proof points for novel MoAs and their potential for differentiation, e.g., Lillys bimagrumab (activin/myostatin type II receptor inhibitor) in combination with semaglutide, aiming to deliver weight loss while preserving muscle mass (phase 2b)