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The SURMOUNT-5 head-to-head trial directly compared tirzepatide to semaglutide and found 47% greater weight loss with tirzepatide at 72 weeks

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The novel Glp-1/Gip dual agonist Da3-Ch is more effective than liraglutide in reducing endoplasmic reticulum stress in diabetic rats with cerebral ischemia-reperfusion injury

From a research standpoint, the main distinction is GLP-1-only pathway interest compared with a dual incretin pathway model

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