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At 15mg weekly, the SURMOUNT-1 trial recorded an average weight loss of 22.5% of body weight
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Furthermore, the trial ran in a contemporary care setting with wider use of SGLT2 inhibitors, and the dosing clearly favored tirzepatide, which was titrated to the maximum tolerated dose up to 15 mg, while dulaglutide remained at a fixed 1.5 mg as in REWIND
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Moreover, the fMLP-induced antagonism of PI3K activity might be PTEN-dependent
