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Extracellular glutamate acts as a competitive inhibitor for cystine uptake via system X c

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Due to the central role of glutamate in ALS, experimental therapies have been investigated and developed targeting glutamate signaling pathways or aimed at enhancing glutamate transport (EAAT2) function in order to restore glutamate homeostasis 34

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2) Cascella R, Evangelisti E, Zampagni M, Becatti M, D'Adamio G, Goti A, Liguri G, Fiorillo C, Cecchi C

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