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There is a long history of abusing drugs or over-the-counter medicines to lose weight diet pills, appetite suppressants, diuretics, enemas and the like, says Dr

58 Median time to the development of a full symptom complex of frequency, urgency, and pain was reported to be two years in one study

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Common gastrointestinal side effects occur in many patients and include: Nausea (most common, typically improving after 4-8 weeks) Vomiting Diarrhea Constipation Abdominal pain or discomfort Decreased appetite These effects result from the drugs' mechanism of actionslowing gastric emptying and affecting gut motilityrather than indicating tissue damage or malignancy