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IL-17A also promotes luminal obstruction through MUC5AC/MUC5B hypersecretion combined with impaired mucociliary clearance, generating mucus plugs measurable by CT-based occlusion scores independent of spirometry ( 2.3.1 Airway remodeling: the progression from EMT to irreversible fibrosis Airway inflammation and structural remodeling are closely intertwined in COPD progression
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