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Second, an in vitro chromosome aberration assay was performed in Chinese Hamster Ovary (CHO) cells treated with AOD9604 (20, 50, 100, 200 g/mL) in the absence or presence of an S-9 metabolic activation system

These may have side effects and varying levels of effectiveness

The l-citrulline vs l-arginine bioavailability comparison shows l-citrulline produces 2-3 times higher plasma arginine levels at equivalent doses

Experimental applications include in vitro cell cultures, ex vivo tissue models, and animal studies designed to observe multi-pathway modulation following peptide exposure

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