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Septic cardiomyopathy (SIC) In a model of LPS-mediated septic cardiomyopathy, some researchers revealed that LPS caused ferroptosis and septic cardiac injury by downregulating GPX4 protein levels and increasing COX-2 [93]
The glutaminase activity of L-asparaginase is not required for anti-cancer activity against ASNS-negative cancer cells, therefore there have been attempt for purifying glutaminase-free L-asparaginase from other sources or engineering L-asparaginase to be glutaminase-free [96, 97]
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