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doi: 10.1055/s-2004-830477 84 ZechmannB.ZellnigG.Urbanek-KrajncA.MllerM

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The critical insight is that the same volume of liquid can contain vastly different amounts of semaglutide depending on how concentrated the solution is

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In clinical trials: Semaglutide: Approximately 7% discontinued due to adverse events Tirzepatide: Approximately 4-7% discontinued due to adverse events (dose dependent) Retatrutide: Approximately 6-10% discontinued due to adverse events (dose dependent) These rates are relatively close, suggesting that despite the differences in mechanism and side effect profiles, all three medications are tolerable for the vast majority of people who start them

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