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Makowski was featured in an article for Nature Reviews Cancer called Are GLP-1 receptor antagonists a magic bullet for cancer? Very little is known, but what were discovering is that it changes lots of different factors that circulate in our blood and that we think are going to affect your immune system, said Makowski

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They include Wegovy and Saxenda, which are licensed for weight loss, and Ozempic and Victoza which are licensed for type 2 diabetes but are often prescribed off-label as a weight-loss aid

Dosing and Titration Require Clinical Judgment GLP-1 medications must be started low and titrated carefully

Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression

For patients who discontinue GLP-1 medications, several evidence-based strategies can help maintain weight loss and metabolic improvements, though success rates vary considerably