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However, the review emphasized that the majority of studies utilized small rodent models, and efficacy in humans remains to be confirmed through adequately powered clinical trials
It's popular in biohacking circles and often pops up in patient consults, but the FDA hasn't approved it for human therapy
Some early data suggested it might actually promote fat storage
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The persistence of acute energy-expenditure and fat-oxidation responses in beta-3-receptor knockout mice indicates that at least some short-term effects occurred without functional beta-3 receptors in that model
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