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participants from Rice University, the University of Kentucky, Scripps College and Kennesaw State University

3.3 Development of unimolecular agents targeting both GIPR and GLP-1R The anti-obesity effects of GIPR antagonism antibody, both alone and in combination with GLP-1RAs, have been demonstrated in preclinical models of mice and monkeys (68, 73)

Chronic fatigue

Omeprazole, a widely prescribed proton pump inhibitor (PPI), reduces gastric acid secretion, whilst antihistamines such as cetirizine, loratadine, and fexofenadine relieve allergy symptoms by blocking histamine receptors

At least 4 weeks on the current dose is the minimum