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The pituitary gland secretes human growth hormone and has many effects on the body, many of which are mediated by IGF, including: Maintaining muscle mass Promotes fat-burning Improves cardiovascular function Boosts stamina Shortens recovery time Declines in growth hormone are associated with less energy, slower metabolism, reduced muscle mass, increased abdominal fat, trouble sleeping, cognitive changes, and increased recovery time

Moreover, exaggerated inflammatory disorders in Covid-19 due to the release of pro-inflammatory cytokines like IL-1, IL-6, and TNF- may lead to the development of systemic inflammation and cytokine storm (Zanza et al