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[11] It is less preferred than hydroxocobalamin for treating vitamin B 12 deficiency because it has a slightly lower bioavailability

doi.org/10.1111/j.1749-6632.2010.05492.x Bock-Marquette, I., et al

5 Journal of Orthopaedic ResearchChang CH et al

It is very important to be aware of where their blood sugar is before [drinking] and where it will likely go as a result, without forgetting to account for food, other drinks, or medication that will also affect blood sugar, he says

This is generally desirable for healing research, but it is the main reason people with active cancer or retinal vascular conditions are advised to avoid these compounds

This means that methyl B12 is more readily absorbed and utilized by the body