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"The risk is undernourishment as you're not able to eat as much as you were prior to being on the drugs," said Williams
By engaging two hormonal pathways, Tirzepatide improves insulin sensitivity and drives larger reductions in appetite and food intake than single-pathway agents
As was pre-specified, eGFR slope was assessed during the acute (baseline to week 16), chronic (week 20 to end of trial) and total (baseline to end of trial) periods
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In the intestine, GLP-1-secreting L cells act as sensors for nutrients, microbes, and inflammatory signals
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