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Data reveal that early non-responders receiving phentermine achieved 5.9% weight loss compared to just 2.8% with placebo after 24 weeks, with over half reaching the clinically meaningful threshold of 5% weight reduction

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Nevertheless, significant methodological limitations persist across the current literature

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It highlights how multireceptor agonists and oral GLP-1-based therapies may reshape the future landscape of obesity and type 2 diabetes treatment by offering more effective and better-tolerated options

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