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However, the clinical advancement of oridonin faced limitations [24, 25], stemming not only from its unclear molecular mechanisms but also due to hydrophobicity and deficient targeting capabilities [26,27,28,29]

GIP consists of 42 amino acids and is synthesized and secreted by endocrine K cells located mainly in the proximal duodenum and jejunum

MT-2 is the short product name for Melanotan II

The role of dipeptidyl peptidase IV in the cleavage of glucagon family peptides: in vivo metabolism of pituitary adenylate cyclase activating polypeptide-(1-38)

Next, add a gentle carbohydrate

doi: 10.3389/fgene.2018.00579 130 de CalignonAFoxLMPitstickRCarlsonGABacskaiBJSpires-JonesTLet al