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greater degree of weight loss is seen when initiating from a higher starting weight [42]

These systems can be useful for studying mechanisms such as cell migration, endothelial signaling, nitric oxide involvement, and tissue-level repair responses, but they do not establish human safety, human efficacy, optimal dosing, or suitability for any medical condition

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Individuals with a BMI of 21 kg/m 2 or less or had a history of acute or chronic pancreatitis, gallbladder disease, medullary thyroid cancer, or type 2 multiple endocrine neoplasia were excluded from the study