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Actually, exendin 4 (an agonist for GLP-1R) is clinically applied and widely used for treatment of T2DM, however exendin 4 has gastrointestinal side effects containing malevolence and vomition

[17] Procedures like sleeve gastrectomy and Roux-en-Y gastric bypass alter gut hormone profiles in ways that partially overlap with GLP-1 medications

it primarily affects motor function due to the loss of dopamine-producing neurons in the substantia nigra, a region of the midbrain

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Terhambatnya enzim ini secara signifikan mempengaruhi kadar melanin, sehingga kulit lebih cerah dan warnanya merata

5), there was an upregulation in Akt-S6K1 phosphorylation (Fig