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Studies have shown that LAC can reverse the decrease in NGF caused by pressure exposure in the central nervous system (97), and normalize the levels of GDNF and ARTN in the peripheral and central nervous systems (98), but there is still a lack of relevant research on the effect of LAC on VEGF in mental illness

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Genome-wide methylation comparisons between 65 DS and 59 NS healthcare workers revealed 21 loci in circadian genes, including PER3 and CSNK1E, to be significantly hypomethylated among NSW, highlighting potential epigenetic mechanisms underlying shift work-associated disease risk 214

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