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If a vial has been left at room temperature for an unknown duration, treat that as a documentation failure and discard it rather than guessing
Zhang X, Bendeck MP, Simmons CA, Santerre JP
For optimal results, combine both approaches
Regulated as a cosmetic, meaning manufacturers cannot claim it cures or prevents disease
The main innovation is convenience: putting two familiar drugs into one tablet. I would not characterize this as an important advance in pain treatment, Mackey added
However, maintaining the blind, especially if there are distinctive side effects associated with the active drug, can be challenging
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