Vasospasm, myocardial infarction, or aortic dissection may precipitate sudden cardiac death
Clinical trials show that side effects become less frequent and less intense with continued treatment over 612 months
Moreover, a retrospective real-world study shows that both GLP1-RA and SGLT-2 inhibitors reduce the 10-year risk for cardiovascular disease in patients with T2D in primary cardiovascular prevention [17], although SGLT-2 inhibitors seem to have a greater cardioprotective benefit compared to GLP-1RA when used for secondary prevention among adults with T2D [18]
Mounjaro is specifically indicated for chronic weight management in adults with obesity or overweight status who also have at least one weight-related condition, such as type 2 diabetes or cardiovascular disease
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We reasoned that high endogenous circulating levels of GLP-1(936) limit the glucagonostatic action of exogenous GLP-1(936)