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[1] If diarrhoea is severe or persistent, your prescriber may recommend remaining at your current dose for an additional week or two before increasing, allowing your digestive system more time to adapt

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[260] [261] Since the total number of microbial and viral cells in the human body (over 100 trillion) greatly outnumbers human cells (tens of trillions), [note 21] [260] [262] there is considerable potential for interactions between drugs and an individual's microbiome, including: drugs altering the composition of the human microbiome, drug metabolism by microbial enzymes modifying the drug's pharmacokinetic profile, and microbial drug metabolism affecting a drug's clinical efficacy and toxicity profile

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Gastrointestinal side effects are the most common for GLP-1based therapies but are generally mild and manageable (127)

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