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Furthermore, the form of vitamin B12 in plant foods has a lower bioavailability than animal derived vitamin B12, and is easily degraded during cooking and food preparation (6)
and a 2025 IV safety pilot in 2 adults found no adverse events [PMID: 40131143]
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NNMT is an enzyme that methylates nicotinamide (a form of vitamin B3), converting it to N1-methylnicotinamide and effectively removing it from the NAD+ salvage pathway
In the REDEFINE 2 study (about 1206 adults with type 2 diabetes and overweight/obesity, 68 weeks), the combination produced a weight reduction of 15.7% versus 3.1% in the placebo group, with a significant improvement in glycemic control