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GHK-Cu, in contrast, delivers copper(II) ions to metalloenzymes such as lysyl oxidase (critical for collagen and elastin cross-linking), superoxide dismutase (antioxidant defense), and cytochrome c oxidase (mitochondrial respiration)

B12 injections are recommended for those who are deficient in vitamin B12

The interaction very rarely results in a pernicious anemia that appears reversible with discontinuation of metformin or with Methylcobalamin, vitamin B12 supplementation

However, research suggests that maintaining adequate B12 levels may help with weight management by improving energy levels[2] and overall metabolic efficiency[1], particularly for those with a deficiency

For keeping vitamin B12 levels up, a common dose is 1000 mcg (1 mg) once a month

Some users specifically report that tirzepatide provides an energy boost after the initial adjustment phase