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To address how Klotho regulates GR protein expression, we performed an in vitro study which showed that culturing with secreted Klotho-deficient medium decreased Nrf2 expression levels while treatment with secreted Klotho increased Nrf2 expression in H9c2 cells (Figure 8), suggesting that secreted Klotho regulates Nrf2 expression
The combination of these peptides may help researchers explore multiple recovery and repair pathways within a single streamlined formulation
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doi: 10.1186/s13041-016-0210-x 190 BookerBImtiazAZaidiM
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