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probiotics may support gut flora balance long-term
31 Thus GLP-1RA may, via GLP-1 receptor signaling in the hypothalamus, interfere with mRNA transcription, translation or the cleavage of ObRb to soluble leptin receptors and thereby down-regulate the production of soluble leptin receptors
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Indeed, the combined use of these medications is suggested to be synergistic and, as reported in a recent meta-analysis, superior outcomes with the addition of a GLP-1 RA to SGLT2i can be observed in type 2 diabetes, although observations of cardiovascular and mortality outcomes are limited [29]
[Abstract] Cell Metab
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