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Table 1 : Summary of SURPASS trials Effect on weight loss Currently the weight loss observed with semaglutide is greater than that reported for other approved anti-obesity medications

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Image Credit: zimmytws / Shutterstock A recent review article published in the Journal of Clinical Investigation summarized the adverse effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dual incretin receptor agonists such as tirzepatide

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High blood sugar levels can damage the small blood vessels in the kidneys, leading to chronic kidney disease (CKD) over time