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These setbacks demonstrate that while GLP-1 RAs show promising biomarker effects in the brain, translating them into meaningful clinical outcomes in neurodegeneration remains an unresolved challenge
Upregulation of cysteine synthase expression in adults and its downregulation in the L3 larval stage suggests that the de novo pathway contributes to the cysteine requirement of mature H
The unfolded protein reaction will weaken weakened translation, upregulation of chaperone proteins, and degradation of misfolded proteins
These warning signs warrant immediate attention and are not the same as mild, manageable side effects from correctly dosed therapy
Published 2024 Aug 30
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