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Key distinctions from growth hormone include [5] : Peptide lacks growth hormone receptor binding domains (specifically binding site 2) Binding site 2 is required for receptor dimerization and activation Competitive binding assays showed AOD9604 cannot compete with hGH for receptor binding Does not function as a growth hormone receptor antagonist Glucose Metabolism Preservation Unlike full hGH, which can induce insulin resistance and hyperglycemia, AOD9604 demonstrates no adverse effects on carbohydrate metabolism

Once reconstituted, the solution should be kept refrigerated and is typically stable for up to 2 months under proper storage conditions

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) 5769 (Blackwell Publishing, 2003)

Summer KH et al

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