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The exact immune mechanisms that cause skin lesions can also contribute to inflammation in other organ systems, resulting in an elevated risk of comorbidities such as psoriatic arthritis, cardiovascular disease, metabolic syndrome, and inflammatory bowel disease (IBD) (Campanati et al

Using Ozempic for weight loss is off-label and often harder to get covered

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In addition, its high molecular weight (57 kDa) prevents renal clearance and prolongs its half-life (133)

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Oxidative stress plays a central role in this melanocyte destruction, with elevated levels of ROS, such as HO, and deficiencies in key antioxidant enzymes creating a toxic environment for these cells