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Similarly, although hepatic dysfunction can occur with large niacin doses (1-3 grams daily over months) causing elevated liver enzymes or jaundice, niacinamide at 100 mg is very unlikely to have any adverse effect on the liver

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Lee, C., Zeng, J., Drew, B

Over the following weeks, patients often report smoother movement, improved tissue quality, and faster recovery from disc irritation, joint inflammation, or tendon strain