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cytochrome P450 isoenzymes (primarily CYP2D6 and 1A2) mediate hepatic N-demethylation, explaining pharmacokinetic variability and drug-drug interaction potential

GLP-1 receptor agonists slow the rate at which food moves from the stomach into the small intestine, prolonging feelings of fullness and helping to reduce overall calorie intake

Adams J, Baral M, Geis E, Mitchell J, Ingram J, Hensley A, et al